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It is a naturally occurring copper peptide complex studied for extracellular matrix remodeling, collagen-related signaling, wound-healing models, and skin-aging research

In studies investigating the extension of gestational weeks in pregnant females with early-onset preeclampsia treated with metformin, metformin (1,0003,000 mg/d) significantly prolonged the expected time for treatment, and shortened the length of stay in the neonatal intensive care unit

GAO X, QIAN M

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The other authors have no potential conflict of interest to declare

This correlated with increases in the level of Cdk inhibitor, p27 Kip1 , without concomitant changes in p16 INK4 , p21 Waf1 , or p53 levels