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Semaglutide itself doesnt directly cause exercise intolerance

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This denatures the peptides molecular structure, rendering it inactive

4 Central GLP-1R pathways linking metabolic regulation and addiction circuits GLP-1 Rs are broadly distributed in brain circuits that play pivotal roles in motivation, including the striatum, hypothalamus, ventral tegmental area (VTA), and extended limbic regions such as the central amygdala and the infralimbic/prelimbic cortex (Pyke et al., 2014

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Contraindications M.V.I