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For some people, that means a GLP-1-based option

Clinical implication Considering the potential for gastric food retention and aspiration risks associated with surgical or endoscopic interventions, the American Society of Anesthesiologists recommends the discontinuation of short-acting GLP-1 RAs one day and long-acting formulations at least 1 week before surgical procedures [27]

Tirzepatide escalates from 2.5mg to 5mg, 7.5mg, 10mg, 12.5mg, and 15mg in 4-week steps

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Given that both SGLT2i and GLP-1 RA demonstrate robust and consistent cardio-renal benefits [14], both agents seem to be an attractive option to fulfil an unmet therapeutic need in type 1 diabetes

Highlights of Prescribing Information: Zepbound (tirzepatide) injection, for subcutaneous use