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78,79 In addition, rare de novo mutations of CHD8, SCN1A, SCN2A, SYNGAP1, ARID1B, GRIN2B, DSCAM, TBR1, KATNAL2, LAMC3 and NTNG1 have been identified, with strong evidence for their association with ASD

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With muco-obstructive lung disease, the failure of mucociliary clearance mechanisms and the shifting of metabolic environments provide a niche for opportunistic bacterial pathogens to overwhelm the existing commensal microbiota