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However, no controlled human trial has compared oral versus injectable AOD-9604 at equivalent systemic doses

This is why combining the two pathways produces additive effects

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In addition to small-molecular antioxidants, extracellular antioxidant defense against ROS is also mediated by SOD mimetic compounds, capable of scavenging superoxide radicals and preventing the formation of damaging peroxynitrite, formed by the reaction between superoxide and nitric oxide