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In addition, unlike studies in human volunteers, which have historically comprised the majority of fMRI research [62] the specific mechanisms that alter functional connectivity in GLP-1R KO mice versus WT mice can be investigated with the full toolset available to rodent neuroscience

That includes medical monitoring, nutritional counseling, support with behavior changes and realistic expectations

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58 BW was significantly reduced (up to 4.9% placebo-adjusted, p=0.013) over 4 weeks

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They are generally mild and self-limiting