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Participants completed a cognitive assessment called the Mini-Mental State Examination (MMSE), which measures attention, memory, and language skills in order to screen for dementia

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Some patients lost up to 25 percent of their body weight

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Ethics declarations Ethics approval All experiments were approved by the local authority veterinary service and by our institutions (University of Trieste, SISSA) authorities and performed in accordance with the Italian law (decree 26/14) and the UE guidelines (86/609/CE, 2007/526/CE, and 2010/63/UE)

The orexigenic effect of peripheral ghrelin differs between rats of different age and with different baseline food intake, and it may in part be mediated by the area postrema