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The cardiovascular outcome question is the single largest open-source efficacy question in the category and the one most likely to either compress or expand the clinical differentiation between triples, duals, and pure GLP-1 in 2027-2028

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The post attributes the variation to differences in metabolism and the pace of weight loss rather than to a well-established direct drug effect, and calls the clinical data widely varying between individuals

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Multiple clinical trials involving young children and adolescents have reported minimal adverse effects