Large, high-fat meals exacerbate nausea and early satiety caused by GLP-1-mediated gastric emptying delay
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Moreover, GLP-1 RAs slow gastric emptying, thereby blunting postprandial glucose and lipid excursions, though diminished tolerance to this effect may develop during prolonged administration of extended-release preparations
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Instead, patients and providers may use lower doses to: Reduce side effects Improve medication tolerance Provide gentle appetite support Maintain weight loss after larger reductions Create a more gradual treatment experience There is currently no universally accepted medical definition of GLP-1 microdosing
You can always eat more if you're still hungry (you probably won't be)