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Int J Mol Sci (2021) 22(3):1273

For maximum weight-loss and hepatic-fat research endpoints, retatrutide leads with 24.2% mean body-weight loss (Phase 2), driven by its unique triple GLP-1/GIP/glucagon receptor agonism

8 GLP-1 is produced by L cells in the lower part of the small intestine and the colon

Its not just the manufacturing process that can differ between compounded and brand-name drugs

Shared Side Effects Whether you choose a shot or a pill, the side effect profiles are very similar because they act on the exact same hormone pathways

If youre using GLP-1 for weight loss or managing type 2 diabetes, you may be wondering: Does it also help with cholesterol? The short answer: yes there is good evidence that GLP-1 can modestly improve cholesterol and overall lipid profiles in some patients