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Although the secretory pathway promotes oxidative folding through the oxidoreductase family, a large proportion of glutathione in the ER lumen is found as mixed disulphides with proteins (Bass et al , 2004)

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People who consistently show stronger effects include those with overweight or obesity, older adults who may have declining muscle carnitine stores, and people with low dietary intake of carnitine

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can be risk factors that increase with age, leading to higher susceptibility to adverse drug reactions [173]