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We show that GIP receptor KO mice exhibit glucose intolerance in the presence of impaired insulin response after 100 and 125 mg glucose, but not after lower doses of glucose

doi: 10.1073/pnas.1703920114 60 LuE.PyatkaN.BurantC

Instead, GHK-Cu appeared to act as a broad-spectrum homeostatic regulator, capable of resetting gene expression patterns in cultured cells towards those characteristic of a younger, more regenerative state

There are various types of mutations, including chromosomal, point, frameshift, and expansion mutations