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Combining ashwagandha and caffeine may cause a particularly complicated response, for example

van de Wouw M, Boehme M, Lyte JM, Wiley N, Strain C, OSullivan O, et al

2018, doi:10.3390/ijms19071987

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While this is a happy outcome, the early parts of this story were one of the very big drivers in my shift from regurgitation of learned talking points to research for a full understanding of my own with everything related to health

Because the peptide has not been extensively studied in humans, researchers do not yet fully understand its potential side effects, drug interactions, or long-term health implications