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Chronic inflammation is now understood to be a major driver of cardiovascular events, making this reduction clinically meaningful beyond just weight loss numbers

When you experience the loss of energy and it takes you longer than usual to perk up, there is normally more than meets the eye

That extra pathway seems to strengthen the effect on appetite and metabolism, and for some patients it actually makes the higher doses more tolerable, not less

Hawkes CH, Del Tredici K, Braak H

Atypical celiac disease as cause of increased need for thyroxine: a systematic study

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