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After intratracheal instillation in male Wistar rats, nickel oxide (Nio) NPs activated the NF-B pathway by upregulation of mRNA and protein expression of NF-B, an inhibitor of B kinase- and nuclear factor-inducing kinase, partially causing pulmonary damage (Chang et al., 2017)

doi: 10.3168/JDS.S0022-0302(99)75242-2 71 LauingerL.KaiserP

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As this study used open-source data without any identifiable personal information, it complies with ethical norms and moral requirements 35