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Oral glutamine supplementation increases seizure severity in a rodent model of mesial temporal lobe epilepsy

The safety profile of dual agonists is similar to pure GLP-1 agonists, with the main difference being slightly higher rates of GI side effects

Nausea typically peaks weeks 4-5 and resolves within 8 days

Sudden discontinuation can lead to rapid weight regain and potential metabolic disturbances, which can undermine the progress made during treatment

GLP-1 is typically used in combination with a reduced-calorie diet and increased physical activity

Analysis of cohorts Our meta-analysis included four studies