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Melanotan-1 and Melanotan-2 exhibit similar stability profiles in lyophilised form (612 months at -20C) but Melanotan-2 demonstrates slightly longer post-reconstitution stability approximately 3540 days versus 28 days for Melanotan-1 due to its cyclic structure, which provides greater resistance to hydrolysis

The goal is smoother drug levels (lower peaks, higher troughs), which can reduce the nausea spike that hits 1-2 days after a full weekly injection

The catch: intact oral glutathione has very low systemic bioavailability

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Retrieved from Zhang, P

Araujo AQ, Silva MT