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There are different ways to get to this metabolic switch

Latif, R., Michalek, K

Because the histone H3K27 methyltransferase EZH2 has a higher affinity for SAM (with a lower Km value) than the H3K4 methyltransferase MLL1, under conditions of limited SAM availability, EZH2 can utilize the substrate more efficiently and maintain its activity relatively well, whereas MLL1 activity is more severely suppressed (51)

GPX4 represents the sole enzymatic system capable of reducing lipid hydroperoxides in mammalian cells, requiring reduced GSH as an essential cofactor for neutralizing lipid peroxides (LPOs)

Compounding scrutiny

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