Duration of Initial Treatment Phase The first treatment phase can last a few weeks to a few months
Gaiteri, P
doi: 10.1038/s41419-023-06216-x
What to watch for: New leakage when coughing, sneezing, laughing, or exercising (stress incontinence) Increased urgency or frequency that wasn't present before starting the medication Worsening of existing incontinence symptoms, particularly alongside constipation Practical steps: Start or continue pelvic floor exercises (Kegels) while on GLP-1 medications -- strengthening the pelvic floor proactively is the best defense against these changes Manage constipation aggressively -- fiber, hydration, and movement all help
GIP and GLP-1 have opposite effects on glucagon release with GIP stimulating glucagon release through an increase of intracellular cyclic adenosine monophosphate levels
Sun, Z., Yang, D., Tang, Z., Ng, D