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A randomized trial found that low-dose semaglutide significantly decreased: The amount of alcohol consumed during laboratory self-administration tasks 22 Weekly alcohol cravings compared to placebo 22 Drinks per drinking day 22 The magnitude of these effects appears substantial, with medium to large effect sizes for grams of alcohol consumed (, 0.48) and peak breath alcohol concentration (, 0.46) 22

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10.3389/fnagi.2021.659402 Front Aging Neurosci

Additional proglucagon-derived peptides, including glicentin and oxyntomodulin, contribute to gastrointestinal regulation and appetite control