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In clinical trials involving different types of stimulants: 0.1% of people who took stimulants had symptoms of psychosis or mania 0% of people who took a placebo (a treatment containing no active drug) had symptoms of psychosis or mania Symptoms of psychosis can include hallucinations, paranoia, and delusions (believing things that arent true)

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A 2024 pooled analysis of the SURMOUNT trials (Aronne et al., Lancet ) found that 4.3% of patients discontinued tirzepatide due to GI side effects