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White blood cells activation also leads to increased production of inflammatory cytokines such as interleukin one (IL-1), interleukin six (IL-6) and tumor necrosis factor alpha (TNF-)

The most important patient-level factors are temperature, freezing, light exposure, moisture, time, and repeated handling

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Furthermore, consulting healthcare providers when fatigue persists can lead to necessary adjustments that enhance energy levels and overall well-being