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Diabetes-associated excess kidney tissue RAS activation increases angiotensin II-mediated glomerular efferent arteriolar vasoconstriction and glomerular hyperfiltration, tubular sodium reabsorption, and signalling through intracellular pathways, resulting in inflammation and oxidative stress [13]

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Some centers may also accept whole blood donations instead of plasma donations if GLP-1 use is the only concern, though this varies by facility