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In its Phase 2 trial in 592 adults with obesity, MariTide produced average weight loss of 12.3% to 16.2% at 52 weeks depending on dose, versus 2.5% with placebo [4]

Furthermore, GSTs are known to facilitate protein S-glutathionylation reactions, and a number of proteins have been shown to be common substrates for GST-mediated protein S-glutathionylation including protein disulfide isomerase (PDI), p53, and peroxiredoxin-VI (Prdx-VI) [10]

Notably, with a significant 29% risk reduction when looking at three or more years exposure to GLP-1RA. They added, Our sensitivity analysis supported the finding of risk reduction when looking at users of GLP-1RA. These findings support the possibility of GLP-1RA being an adjunctive therapy to IOP-reducing eye drops in glaucoma management, the authors argue

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Heres what we know and why clinicians are exploring this promising approach

Animal toxicology can identify possible hazards, but species differences prevent it from fully predicting human safety