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Mitochondrial signalling and homeostasis: From cell biology to neurological disease

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b , Scatter plot depicting protein ligandability change versus abundance change with indicated probes after Tuni treatment in HEK293T cells

Ligand binding activates adenylyl cyclase, elevating intracellular cAMP and triggering PKA-mediated phosphorylation of downstream steroidogenic targets including CYP11A1, CYP17A1, and 3-HSD

By using SuTEx fragments, they discovered JWB152 and JWB198 as efficient ligands of GSTP1-1 Y8