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1d,e and Extended Data Fig
Earlier studies largely focused on larger peptide-based GLP-1s, such as semaglutide, which were shown to suppress hunger by targeting appetite-regulating networks in the hypothalamus and hindbrain
Cons: Results may vary based on individual factors like diet and exercise
And in 2022, I started Mounjaro (tirzepatide), which is FDA-approved for type 2 diabetes but used off-label for weight loss
At present, the studies of EX on non-diabetic obesity mainly include 152 cases of simple obesity (weight loss of 5.1 kg) (54), 60 cases of polycystic ovary syndrome (weight loss of 3.2-6.0 kg) (55), and 10 cases of metabolic syndrome (weight loss of 3.7 kg) (56), among which the most common adverse reaction is still vomiting
116 Study details | Glucagon-like peptide-1 receptor agonist (GLP-1 RA) and diet in inflammatory bowel disease (IBD) patients | ClinicalTrials.gov
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