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6-di-O-acetyl-2-deoxy-α-D-galactopyranosyl}-N α-(fluoren-9-yl-methoxycarbonyl)-L-Threonine
Azido-triethyleneglycol-functionalized M6P Ligand
/ β-LacNAc-PEG3-Thiol / β-LacNAc-PEG3-SH
Galβ1-4GlcNAc) building block
C27H38D6O / 390
PE131000: α-GalNAc-PEG3-Alkyne label-new 6-di-O-acetyl-2-deoxy-α-D-galactopyranosyl}-N α-(fluoren-9-yl-methoxycarbonyl)-L-ThreonineC17H29NO9 391. 41 An D N acetylgalactosamine (GalNAc) ligand equipped with a terminal alkyne through a hydrophilic PEG3 spacer. The alkyne couples to azide functionalized partners via copper catalyzed azide alkyne cycloaddition (CuAAC), forming stable 1,2,3 triazole linkages. This compound enables the construction of hepatocyte targeted therapeutics and research tools that exploit the asialoglycoprotein receptor (ASGPR), which is highly expressed on
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