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In PD mouse models, reducing endogenous lactate or directly inhibiting histone lactylation suppresses microglial activation, lowers pro-inflammatory cytokine release, and improves motor outcomes (Qin et al., 2025)

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Fan X, Xie M, Zhao F, Li J, Fan C, Zheng H, et al

Patients with a documented history of prominent positive symptoms of schizophrenia but currently exhibiting no substantial positive symptoms were deemed to satisfy ICD-10 criteria for residual schizophrenia if they exhibited appreciable negative symptoms, and/or impaired occupational and/or social function

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