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Research has identified multiple mutations in the gene for DAO that result in reduced function of the enzyme
It appears that the anaplerotic enzyme pyruvate carboxylase participates directly or indirectly in several metabolic pathways which are important for glucose-induced insulin secretion, including: the pyruvate/malate cycle, the pyruvate/citrate cycle, the pyruvate/isocitrate cycle and glutamate-dehydrogenase-catalysed -ketoglutarate production
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Furthermore, it appears that this process favors the production of nanosheets with a large structure, providing a specific surface, which is important for fixing metals [73]