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Studies confirm a link between the immune system and age-related changes in the central nervous system in dogs [89,100]

FOXO4-DRI is a senolytic peptide that targets p53, a crucial tumor suppressor that prevents genomic mutations 34

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In contrast to other proteins that do not engage FcRn, the two ligands are prevented from progressing to the lysosomes for degradation by binding to the receptor in early sorting endosomes 41,43,47,49,50