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3 Pharmacotherapeutic potential of GIP and GLP-1 3.1 Therapeutic potential in T2DM Despite being the first identified incretin, GIP was initially disregarded as a viable therapeutic approach for T2DM

Currently, the use of GLP-1 RAs in individuals with a personal or family history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia syndrome type 2 (MEN2) is contraindicated

Oral semaglutide, a glucagon-like peptide 1 analogue, controls blood glucose and results in significant body weight loss in patients with type 2 diabetes

Peptides 125 , 170174 (2020)