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Possibly, this toxicity, in addition to lower esophageal sphincter and pyloric sphincter failure, involves sole NSAIDs-gastric ulcers, presenting with aspirin (and thereby, aspirin was used intragastrically) (14) and ibuprofen (10), as well as with those agents combining gastric and small intestine ulcers (i.e., diclofenac (9, 11))

(2025) 13:e70276

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Nature 433:769773 Lindpaintner K (2002) The impact of pharmacogenetics and pharmacogenomics on drug discovery