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By far the most unexpected result of the present study is the defect in cAMP generation that we have measured downstream of GLP-1 stimulation for the triple AA phospho-null mutant compared to the WT receptor in our -cell system

Bendotti et al

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A well-known method of repressing transcription is methylation close to gene promoters

Inhibition of EZH1 and EZH2 Restores Chemosensitivity of Leukemia Stem Cells in Acute Myeloid Leukemia by Recruitment of Quiescent AML Stem/Progenitor Cells