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Deletion sequences (missing amino acids), racemization (wrong chirality), and oxidation products can occur without proper controls

(5) Jiamin Huang, Pipasha Khatun, Yuqing Xiong, Bingrui Liu, Yisu Zhao, and Quanjun Lyu (2023) Intakes of folate, vitamin B6, and vitamin B12 and cardiovascular disease risk: a national population-based cross-sectional study Frontiers in Cardiovasular Medicine, 2023 Nov 14, Volume 10, Page 1237103 (6) Karem Alzoubi, Omar Khabour, Noor Hussain, Sayer Al-azzam, and Nizar Mhaidat (2012) Evaluation of vitamin B12 effects on DNA damage induced by pioglitazone Mutation Research/Genetic Toxicology and Environmental Mutagenesis, Volume 748, Issues 12, 9 October 2012, Pages 48-51

Despite numerous clinical trials, comprehensive comparative analyses that offer clear guidance for clinical practice are limited

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