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Experimental studies have demonstrated that following the intracisternal injection of exogenous tau in wild-type mice, plasma tau levels rise significantly within minutes, suggesting rapid systemic distribution [55]

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Conversion of acetylcarnitine to carnitine was higher than the average renal clearance of acetylcarnitine, suggesting that a large proportion of the acetyl moieties of the exogenously administered acetylcarnitine is either rapidly used in biosynthesis and stored (in a form other than acetylcarnitine), or hydrolyzed [106]