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Among pharmacologic options, glucagon-like peptide-1 receptor agonists (GLP-1RAs) have gained particular interest over recent years (33, 34)

This amplifies the many challenges associated with GLP-1s, like gastrointestinal side effects, nutrient inadequacies, muscle and bone loss, low long-term adherence, weight regain, and high costs

Roy practices at the Hospital for Endocrine Surgery in Tampa and brings a wealth of experience to this essential discussion

Lira (GLP-1R) can reduce the occurrence of hepatic steatosis in vivo and in vitro by enhancing autophagy and lipid degradation through the GLP-1R-transcription factor EB (TFEB)-mediated autophagy lysosomal pathway [37]

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However, GLP-1 medications slow gastric emptying, making fiber intake particularly important for managing common side effects like constipation while supporting blood sugar control and satiety