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Myeloid-derived suppressor cells (MDSCs) and activated tumor-associated macrophages express ARG1, which consumes arginine to form a microenvironment that is not conducive to T cells, resulting in tumor immunosuppression (Rodriguez et al., 2017

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4 to 8 units per day on a 1 ml insulin syringe, equal to 1 to 2 mg per day

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