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Weight Loss is Greater, and Body Composition Profile is More Favorable with SAR425899 due to a Greater Deficit in Energy Intake Under conditions of calorie restriction, the mean change from baseline for body weight (adjusted for baseline weight) on Days 5, 9, 16, and 20 was 2.111.11, 2.511.35, 3.101.39, and 3.681.37 kg for placebo, and 1.851.17, 2.561.41, 3.991.46, and 4.831.44 kg for SAR425899 (p0.0001 and p=0.002 for time and interaction time group effects, respectively) (Figure 1A)

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Br J Obstet Gynaecol 1978;85:818-820