Nausea Real-world studies confirm that nausea is the most frequent GI AE that arises upon initiation of GLP-1 RA [20,43,44]
Convenient automatic refills
Avoiding high-fat, greasy, or heavily processed foods is critical, as these are difficult for a slowed stomach to digest
Call a healthcare provider right away if you have any of these symptoms, especially if they are new, worse, or worry you: Thoughts about suicide or dying Attempts to commit suicide New or worse depression New or worse anxiety Panic attacks An extreme increase in activity and talking (mania) Feeling agitated or restless Trouble sleeping (insomnia) New or worse irritability Acting aggressive, being angry or violent Acting on dangerous impulses Other unusual changes in behavior or mood Topiramate may lower bone mineral density
While bruising can occur with subcutaneous injections too, deeper bruising, the kind that feels tender to pressure and takes longer to appear, often suggests muscle penetration
STEP trials showed 1522% weight loss with semaglutide across 68 weeks