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Because of their malfunctioning kidneys and renal clearance, the B12 remained in the blood, and serum values rose from an average of 422pmol/L to 54,000pmol/L, without side effects

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Mutations that inactivate PTEN lead to a constitutively active PI3K/AKT/mTOR signalling pathway and ultimately may result in abnormal protein synthesis

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However, the IGF-I knockout mouse is less growth retarded than the IGF-I and GHR double knockout, suggesting that GH also has IGF-I-independent effects (Lupu et al ., 2001)

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