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Figure 1 Furthermore, SAM serves as a methyl donor, methylating DNA and proteins, including histones (Zade et al., 2023), which in turn influences epigenetic regulation, and gene expression ( Figure 1 )

Remarkably, the combination of these drugs induced ferroptosis and significant cell death in p53-mutated hypopharyngeal squamous cell carcinoma

Glutathione peroxidases 4 (GPX4) is a selenocysteine-containing, and GSH-dependent monomeric enzyme (Kelner and Montoya, 1998

Regulatory agencies will want strong evidence of tissue targeting, off-target screens, and long-term follow-up of fertility and offspring outcomes

doi: 10.3390/biomedicines9101300

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