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Improved blood sugar control : By increasing insulin secretion, they help stabilise post-meal blood glucose, making them particularly effective for people with insulin resistance or type 2 diabetes
NTS GLP-1R neurons, sensitive to nutritive stimuli, induced satiety without aversion, whereas AP GLP-1R neurons elicited strong nausea-like behavior in mice
By lowering blood pressure, reducing blood glucose, and decreasing glomerular hyperfiltration (excessive kidney workload), semaglutide preserves kidney function and can prevent or delay the need for dialysis
What matters is the resulting concentration: extremely dilute solutions (under ~0.5 mg/mL) require larger injection volumes per dose, which becomes uncomfortable and can shift absorption kinetics
