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Ecnoglutides cAMP-bias aims for greater efficacy with fewer side effectsa distinction confirmed in both preclinical and Phase 3 data

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In SICLOPPS, split-intein domains, comprising separately expressed N-terminal (IN) and C-terminal (IC) segments of an intein, reassemble within cells to form an active intein (Scheme )

Although upregulation of CXCL8 was not noticed in this dataset but a linked gene, CXCL2, was identified as upregulated

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