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SGLT2 inhibitors were chosen as the comparator given they are guideline-recommended second-line glucose-lowering medication and share similar cardiovascular benefits with GLP-1RA, which helps reduce confounding by indication

For type 2 diabetes indications , most commercial insurance plans, Medicare Part D, and Medicaid programs provide coverage for GLP-1 receptor agonists, though prior authorization requirements are nearly universal

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symptoms of mycoplasma contamination are more subtle, and careful monitoring of culture morphology and regular testing are necessary to detect this type of contamination

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