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Early concentrations of paracetamol in the brain (33) appear to be well-timed with the period of the rising concentration in various brain structures (33) and coincide with the noted brain damage and with the appearance of generalized seizures in the present study

229 Conversely, SIRT1 facilitates transcriptional activation of the BECN1 gene by deacetylating histone H4 at lysine 16, thereby establishing a chromatin configuration permissive for autophagy induction under nutrient-deprived conditions

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