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Those who are considering weight loss medication may also be concerned about rare but serious long-term risks, which can include: Cardiovascular concerns (Increased heart attack risk in certain populations) Gallbladder disease Pancreatitis Other limitations include: Cost: Up to $1,000-1,200/month if not covered by insurance Supply shortages: Ongoing demand has outpaced availability Needle administration: Daily or weekly subcutaneous injections may deter some users For those with health conditions like heart disease, a history of pancreatitis, or certain genetic risks, these drugs may not be appropriate

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Li H, Lee J, He C, Zou MH, Xie Z

Leukemia 23(10):1755-1762, 2009

10.1039/d1na00145k 143

Mansell NS, Rhon DI, Meyer J, Slevin JM, Marchant BG