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In addition, CS contains a large amount of oxidants (Pryor and Stone, 1993), and COPD patients have high levels of oxidative stress in their lungs (Zuo et al., 2014)

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Cleavage of the extracellular domain of IR by membrane-bound matrix metalloproteinase 14 (MT1-MMP/MMP14) Membrane type 1 matrix metalloproteinase (MT1-MMP/MMP14), a membrane-bound Zn-containing endopeptidase, cleaves a wide variety of substrates ranging from the extracellular matrix to growth factor receptors, e.g., IR and lymphatic vessel endothelial hyaluronan receptor-1 (LYVE-1), and these experiments were done as described elsewhere with some modifications 24,64,65

It has been linked to gastrointestinal issues and kidney complications