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To highlight this impediment, the US public system (the largest healthcare market in the world) is explicitly legislated to exclude weight loss (and weight gain) drugs from reimbursement, despite extensive ongoing lobbying by the drug companies (the last failed attempt was in July 2023)
The FDA says compounded drugs should only be used when a patients medical needs cannot be met by an FDA-approved drug, and it warns that poor compounding can lead to quality problems such as contamination or too much or too little active ingredient
Inclusion/Exclusion Criteria and Adverse Events were listed in Table S1a
Yes, topiramate increases the risk of kidney stones, particularly calcium phosphate stones, by inhibiting carbonic anhydrase in the kidney