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Tirzepatide should be discontinued if pancreatitis is suspected, and patients should be educated to recognize symptoms including severe, persistent abdominal pain that may radiate to the back

For peripheral tissues such as liver and pancreas, it is difficult to identify reference tissues (which should exhibit similar perfusion and tracer delivery, but without receptor expression)

see Figure 1 taken from a population-based cohort study of 3.6 million adults in the UK

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Reduction of leptin levels by four cardiac hormones: Implications for hypertension in obesity

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