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This is primarily defined by legislation called The Human Medicines Regulations 2012

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Malabsorption : Some people may have difficulty absorbing vitamin B12 from the diet due to certain medical conditions or the use of certain medications, such as proton pump inhibitors (PPIs) or H2 blockers, which reduce stomach acid production

Two samples were identified as markedly different from the remaining samples

Managing and treating side effects Despite best practices, side effects sometimes occur